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新西兰护理学作业代写 抗体治疗用途

由于其独特的结构和多种形式,单克隆抗体显示了为什么它们是伟大的治疗用途,但也为什么他们是具有挑战性的分子发展。有一些因素对抗体设计是必要的,应该记住:构象稳定性,结合亲和力和特异性,胶体稳定性,效应体功能,抗体设计,细胞毒性(抗体药物偶联物),和双特异性。这些属性中的每一个都可以很容易地按顺序进行更改,但是,一个属性的更改可能会导致其他属性的不足。同时优化这些类别是禁止的,因为这样一个事实,这么大的图书馆必须建立适应修改。抗体设计首先要关注的是能够识别具有高亲和力和特异性的抗原。要修改这一点,必须对cdr进行修改,有几种方法可以重新设计单克隆抗体,如从头设计和基序嫁接。从头设计实质上是重新开始。为了重新设计单波束的CDR,采用了一种计算方法OptCDR(最优互补确定区域)。这是为了设计而创造的.

新西兰护理学作业代写 抗体治疗用途

Due to their unique structure and various forms mAbs show why they are great for therapeutic use but also why they are challenging molecules to develop. There are factors that are essential to antibody design and that should be kept in mind: conformational stability, binding affinity and specificity, colloidal stability, effector function, antibody design, cytotoxicity (antibody-drug conjugates), and bi-specificity. Each of these properties can be easily changed sequentially however, changes in one property can lead to deficiencies in others. While optimizing these categories simultaneously is prohibitive due to the fact such a large library must be built to accommodate the modifications.The first thing to focus on with antibody design is to be able to have it recognize the antigen with high affinity and specificity. To modify this, changes must be made in the CDRs, there are a few approaches that allow the redesigning of mAbs such as de novo design, and motif-grafting.De Novo design is essentially starting anew. To redesign the CDRs of the mAb a computational approach is taken named OptCDR (Optimal Complementarity Determining Regions). This has been created to design

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